Perry J Blackshear Selected Research

Inflammation (Inflammations)

11/2022	Clinical implications of tristetraprolin (TTP) modulation in the treatment of inflammatory diseases.
1/2022	ZFP36L1 Regulates Fgf21 mRNA Turnover and Modulates Alcoholic Hepatic Steatosis and Inflammation in Mice.
1/2021	Tristetraprolin Promotes Hepatic Inflammation and Tumor Initiation but Restrains Cancer Progression to Malignancy.
1/2021	The RNA-binding protein tristetraprolin regulates RALDH2 expression by intestinal dendritic cells and controls local Treg homeostasis.
1/2021	Tristetraprolin Prevents Gastric Metaplasia in Mice by Suppressing Pathogenic Inflammation.
1/2021	Tristetraprolin expression by keratinocytes protects against skin carcinogenesis.
10/2020	Bone marrow deficiency of mRNA decaying protein Tristetraprolin increases inflammation and mitochondrial ROS but reduces hepatic lipoprotein production in LDLR knockout mice.
1/2020	Tristetraprolin Overexpression in Non-hematopoietic Cells Protects Against Acute Lung Injury in Mice.
1/2020	Tristetraprolin Regulates TH17 Cell Function and Ameliorates DSS-Induced Colitis in Mice.
11/2019	The mRNA-binding Protein TTP/ZFP36 in Hepatocarcinogenesis and Hepatocellular Carcinoma.

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Perry J Blackshear Research Topics

Disease

30	Inflammation (Inflammations) 11/2022 - 09/2005
14	Arthritis (Polyarthritis) 11/2022 - 01/2004
11	Neoplasms (Cancer) 01/2021 - 06/2007
10	Hyperplasia 11/2022 - 01/2004
6	Rheumatoid Arthritis 11/2022 - 01/2004
6	Cachexia 11/2022 - 09/2011
5	Dermatitis 11/2022 - 08/2013
4	Atherosclerosis 10/2020 - 09/2011
3	Insulin Resistance 11/2019 - 10/2018
3	Female Infertility 01/2018 - 10/2004
2	Psoriasis (Pustulosis Palmaris et Plantaris) 11/2022 - 06/2017
2	Autoimmune Diseases (Autoimmune Disease) 11/2022 - 06/2011
2	Crohn Disease (Crohn's Disease) 11/2022 - 07/2009
2	Carcinogenesis 01/2021 - 01/2019
2	Hepatocellular Carcinoma (Hepatoma) 01/2021 - 11/2019
2	Colitis 01/2020 - 10/2019
2	Lung Injury 01/2020 - 01/2014
2	Congenital Abnormalities (Deformity) 01/2019 - 01/2018
2	Infections 03/2014 - 01/2014
2	Endotoxemia 12/2013 - 05/2012
2	Myositis (Idiopathic Inflammatory Myopathies) 03/2008 - 03/2006
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 11/2022
1	Obesity 01/2022
1	Cardiomyopathies (Cardiomyopathy) 01/2022
1	Hypertrophy 01/2022
1	Fibrosis (Cirrhosis) 01/2021
1	Non-alcoholic Fatty Liver Disease 01/2021
1	Metabolic Diseases (Metabolic Disease) 01/2021
1	Liver Neoplasms (Liver Cancer) 01/2021
1	Metaplasia 01/2021
1	Uveitis 01/2020
1	Blindness (Hysterical Blindness) 01/2020
1	Acute Lung Injury 01/2020
1	Pneumonia (Pneumonitis) 01/2020
1	Fetal Diseases (Embryopathy) 01/2019
1	Hydrocephalus (Hydrocephaly) 01/2018
1	Iron Deficiencies 01/2018
1	Holoprosencephaly (Arhinencephaly) 01/2018
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 02/2016
1	Chromosome Deletion (Deletion, Chromosome) 12/2014
1	Thrombosis (Thrombus) 12/2014
1	Hyperthermia 07/2014

Drug/Important Bio-Agent (IBA)

34	thiamine triphosphorate (TTP)IBA 11/2022 - 01/2004
25	TristetraprolinIBA 01/2021 - 01/2004
17	CytokinesIBA 11/2022 - 01/2004
17	Messenger RNA (mRNA)IBA 01/2022 - 01/2004
14	Proteins (Proteins, Gene)FDA Link 11/2022 - 01/2004
7	Carrier Proteins (Binding Protein)IBA 01/2021 - 03/2010
6	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2020 - 01/2004
5	RNA-Binding Proteins (RNA-Binding Protein)IBA 01/2021 - 07/2010
3	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 10/2018
3	Interleukin-10 (Interleukin 10)IBA 03/2014 - 07/2009
2	fibroblast growth factor 21IBA 01/2022 - 12/2018
2	Anti-Bacterial Agents (Antibiotics)IBA 01/2021 - 07/2016
2	Diethylnitrosamine (N-Nitrosodiethylamine)IBA 01/2021 - 11/2019
2	ElementsIBA 01/2021 - 12/2014
2	LipidsIBA 11/2019 - 07/2014
2	RNA (Ribonucleic Acid)IBA 12/2018 - 07/2010
2	Imiquimod (Aldara)FDA LinkGeneric 06/2017 - 02/2016
2	Myristoylated Alanine-Rich C Kinase SubstrateIBA 10/2015 - 06/2006
2	Apolipoproteins E (ApoE)IBA 07/2014 - 09/2011
2	AutoantibodiesIBA 03/2008 - 03/2006
1	ChemokinesIBA 11/2022
1	Sirolimus (Rapamycin)FDA Link 01/2022
1	Mechanistic Target of Rapamycin Complex 1IBA 01/2022
1	Choline (Choline Chloride)IBA 01/2021
1	CarcinogensIBA 01/2021
1	Methionine (L-Methionine)FDA Link 01/2021
1	Tamoxifen FDA LinkGeneric 01/2021
1	spasmolytic polypeptideIBA 01/2021
1	oxidized low density lipoproteinIBA 10/2020
1	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2020
1	Lipoproteins (Lipoprotein)IBA 10/2020
1	interstitial retinol-binding proteinIBA 01/2020
1	Interleukin-17 (Interleukin 17)IBA 01/2020
1	LipopolysaccharidesIBA 01/2020
1	sodium sulfate (sodium bisulfate)FDA LinkGeneric 10/2019
1	Dextrans (Dextran)FDA Link 10/2019
1	NexusIBA 01/2019
1	SirtuinsIBA 01/2019
1	Insulin (Novolin)FDA Link 10/2018
1	IronIBA 01/2018
1	Iron-Regulatory Proteins (Iron-Responsive Element Binding Proteins)IBA 01/2018
1	Protein Isoforms (Isoforms)IBA 01/2018
1	Electron Transport Complex III (Coenzyme Q-Cytochrome-c Reductase)IBA 01/2018
1	Histone Deacetylase InhibitorsIBA 01/2018
1	givinostat hydrochlorideIBA 01/2018
1	Pharmaceutical PreparationsIBA 07/2016
1	Dactinomycin (Actinomycin)FDA LinkGeneric 07/2016
1	CollagenIBA 02/2016
1	Monomeric GTP-Binding ProteinsIBA 10/2015
1	Protein Kinases (Protein Kinase)IBA 10/2015
1	Alanine (L-Alanine)FDA Link 10/2015
1	Thromboplastin (Tissue Factor)IBA 12/2014
1	Membrane Glycoproteins (Membrane Glycoprotein)IBA 12/2014
1	ApolipoproteinsIBA 07/2014

Therapy/Procedure

2	Therapeutics 01/2021 - 01/2004
1	Bariatric Surgery 01/2022
1	Adrenalectomy 01/2021
1	Ligation 10/2015